2 WEEKS
OF TREATMENT FOR
LASTING IBS-D SYMPTOM RELIEF*

Connect with a Nurse Navigator† to learn more about XIFAXAN or receive additional resources

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*In clinical trials, more patients taking XIFAXAN vs. placebo for 2 weeks had relief of IBS-D symptoms (inc. abdominal pain & diarrhea) during the month following treatment. Median duration of symptom relief was 10 weeks (range of 6 to 24 weeks ). You can be re-treated up to 2 times if symptoms return. Individual results may vary. IBS-D = irritable bowel syndrome with diarrhea.

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2 weeks of XIFAXAN provided symptom relief in adults with IBS-D*

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Lasting relief from abdominal pain and diarrhea*

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#1 doctor-prescribed medication approved for IBS-D†

XIFAXAN Strong Recommendation Seal

Recommended by the American College of Gastroenterology‡

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“Honestly, I wish that I had prioritized my health sooner and didn't delay finding this treatment I could have had. It is possible to treat your IBS-D.”

— JENNIFER

Watch Jennifer and other people talk about their experiences with IBS-D—and how they found relief.

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Take our IBS-D quiz

Answer a few questions to show your doctor and learn about your IBS-D relief options.

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FAQs

If you experience diarrhea and abdominal pain, you may have IBS-D. Only a qualified doctor can diagnose IBS-D, so discuss your symptoms with your doctor.

Download a Doctor Discussion Guide.

XIFAXAN is a prescription antibiotic that works mainly in the digestive tract. XIFAXAN 550-mg tablets are indicated for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults. It is a 2-week treatment. In clinical trials, patients experienced lasting relief from abdominal pain and diarrhea.* You can be treated again up to 2 times if symptoms come back. Talk to your doctor before taking XIFAXAN if you have severe hepatic (liver) impairment, as this may cause increased effects of the medicine.

The most common side effects of XIFAXAN in IBS-D were nausea (feeling sick to your stomach) and an increase in liver enzymes. Please click here for additional Important Safety Information.

*In 2 studies, more patients taking XIFAXAN vs placebo for 2 weeks had relief of IBS-D symptoms during the month following treatment. Average time of symptom relief was 10 weeks (range of 6 to 24 weeks). You can be treated again up to 2 times if symptoms come back. Individual results may vary. Learn more.

In clinical trials, XIFAXAN provided lasting relief of abdominal pain and diarrhea.* If you’ve been living with IBS-D symptoms, it may be time to talk with your doctor about XIFAXAN. Learn more about results with XIFAXAN.

The most common side effects of XIFAXAN in IBS-D were nausea (feeling sick to your stomach) and an increase in liver enzymes. Please click here for additional Important Safety Information.

*In 2 studies, more patients taking XIFAXAN vs placebo for 2 weeks had relief of IBS-D symptoms during the month following treatment. Average time of symptom relief was 10 weeks (range of 6 to 24 weeks). You can be treated again up to 2 times if symptoms come back. Individual results may vary. Learn more.

If you have additional questions about XIFAXAN or available resources and support, you can connect with a Nurse Navigator* today.

Chat with a Nurse Navigator to learn more about XIFAXAN.

*Patient is not eligible to use our Navigator services if he/she participates in or seeks reimbursement or submits a claim for reimbursement to any federal or state healthcare program with prescription drug coverage.

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Copay Card

Save on your XIFAXAN prescription

The XIFAXAN Instant Savings Copay Card provides most eligible§ commercially insured patients help with their monthly copays for XIFAXAN.

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§Patient is not eligible if he/she participates in or seeks reimbursement or submits a claim for reimbursement to any federal or state healthcare program with prescription drug coverage, such as Medicaid, Medicare, Medigap, VA, DOD, TRICARE, or any similar federal or state healthcare program (each a Government Program), or where prohibited by law. Patient must be enrolled in, and must seek reimbursement from or submit a claim for reimbursement to, a commercial insurance plan. Offer excludes full cash-paying patients. Maximum benefits and other restrictions apply. Visit https://xifaxan.copaysavingsprogram.com/ or call 1-866-XIFAXAN for full eligibility criteria, terms and conditions.

*In clinical trials, more patients taking XIFAXAN vs placebo for 2 weeks had relief of IBS-D symptoms during the month following treatment. Average time of symptom relief was 10 weeks (range of 6 to 24 weeks). You can be treated again up to 2 times if symptoms come back. Individual results may vary.

†Based on aggregated total of all prescribers as of June 2022.

‡The American College of Gastroenterology has given XIFAXAN (rifaximin) a strong recommendation to treat global IBS-D symptoms. This is based on moderate clinical information.

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INDICATIONS

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

IMPORTANT SAFETY INFORMATION

  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.
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INDICATIONS

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

IMPORTANT SAFETY INFORMATION

  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • Talk to your healthcare provider before taking XIFAXAN if you have severe hepatic (liver) impairment, as this may cause increased effects of the medicine.
  • Tell your healthcare provider if you are taking drugs called P-glycoprotein and/or OATPs inhibitors (such as cyclosporine) because using these drugs with XIFAXAN may lead to an increase in the amount of XIFAXAN absorbed by your body.
  • In clinical studies, the most common side effects for XIFAXAN were:
    • - HE: Peripheral edema (swelling, usually in the ankles or lower limbs), constipation, nausea (feeling sick to your stomach), fatigue (feeling tired), insomnia (trouble sleeping), ascites (a buildup of fluid in the abdomen), dizziness, urinary tract infection, anemia (low red blood cell levels), and itching
    • - IBS-D: Nausea (feeling sick to your stomach) and an increase in liver enzymes
  • XIFAXAN may affect warfarin activity when taken together. Tell your healthcare provider if you are taking warfarin because the dose of warfarin may need to be adjusted to maintain proper blood-thinning effect.
  • If you are pregnant, planning to become pregnant, or nursing, talk to your healthcare provider before taking XIFAXAN because XIFAXAN may cause harm to an unborn baby or nursing infant.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/ or call 1-800-FDA-1088.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/ or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183
Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183

Please click here for full Prescribing Information. RX only.

XIFI.0150.USA.23V2.0